химиотерапия лейкозов

Инфицированность ВПЧ type 18 contacts the worse forecast Walker (1989) and Burnett (1992), Riou (1990) and Higgins (1991) specify higher parameters of death rate in case of ВПЧ-NEGATIVE tumours, in researches Hоweey (1991), Sebbelov (1991), Chen (1993), Ikenberg (1994) similar law has not been revealed [цит. On 14]. However results of similar researches are put under doubt by the modern data on revealing sequences virus генома a method полимеразной chain reaction in 95-100 % of cases плоскоклеточного a cancer and аденокарцином шейки a uterus [18,23]. The age of patients, on one data, is not connected to молекулярно-genetic determinants of infection ВПЧ while other authors specify, that ВПЧ type 18 or ВПЧ type 16 come to light at younger patients is more often. Stage FIGO, by results of one researches, has not been connected to молекулярно-genetic determinants of infection ВПЧ [14,18]. Подробнее...

Unresolved there is a question on optimum duration of chemotherapy of the first line. Today it is possible to recommend an individual approach in each concrete case. At a stage of chemotherapy of the first line it is necessary to aspire to achievement of full regress with disappearance of all displays of illness including normalization of level СА-125, and then to fix the achieved effect carrying out of 2-3 more additional rates. At achievement of partial regress it is necessary to continue chemotherapy till the moment when during two last rates stabilization of illness is marked, estimating on the sizes of residual tumoral weights and concentration of tumoral markers. By own experience I can tell, that in these cases at the majority of patients the number of courses of treatment will make from 6 up to 12, but not less than 6. In case of stabilization of illness it is necessary to limit volume of treatment by 6 rates after which end therapy can be stopped up to attributes of progressing or it is continued with use of modes of the second line depending on the general{common} condition of the patient and its{her} attitude{relation} to the further carrying out chemotherapy. At progressing illness it is necessary to pass to modes of the second line of chemotherapy. Подробнее...