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The cellular lines received from tumours, and биоптаты from патологически the changed fabrics long time remained a unique material for studying mechanisms папилломавирусной infections. Unsuccessfulness of reproduction папилломавируса in culture of cells{cages}, absence convincing серологических tests for a virus infection, variety of displays цитопатических effects of a virus and subjectivity of an estimation and interpretation a virus - induced cytologic and гистопатологических changes constrained the further researches. Подробнее...

During many years was considered, that usual, flat (ювенильные) and генитальные warts are caused by one type папилломавируса, and distinctions in clinical current are caused by distinctions in localization. Sights at a pathology кондилом шейки a uterus have been considerably reconsidered after Meisels, Fortin (1976), Purola, Savia (1976) have described генитальные flat and inverted (эндофитные) кондиломы, having defined{determined} their basic difference from кондилом other localizations, and postulated цитоморфологические attributes папилломавирусной infections: коилоцитоз or баллонирование the cells{cages}, described increased, гиперхромными the nucleus surrounded with a precise zone of light cytoplasm. Later with the help электронно-microscopic, иммуногистохимических and ДНК-гибридизационных researches it has been confirmed them папилломавирусная этиология [9,20]. Подробнее...