рак щетовидной железы

Middle age of patients has made 64 years; 84 % had positive рецепторный the status, 34 % - positive axillary лимфоузлы, 21 % of patients received адъювантную chemotherapy earlier. Reception анастрозола associated with reduction of risk рецидивирования on 17 % (1 % in absolute values) in comparison with тамоксифеном (р=0,0129); the combination анастрозола and тамоксифена did not differ on efficiency from monotherapy тамоксифеном. It is necessary to note, that reception анастрозола associated also with essential decrease{reduction} in risk of development контралатерального a cancer dairy железы (р=0,0068). Костно-muscular pains, and also crises of bones much more often were observed in group анастрозола while тромбоэмболические episodes and gynecologic complications, including a cancer эндометрия, much more often met in group тамоксифена. Thus, анастрозол it can be considered{examined} as alternative тамоксифену at patients in менопаузе with positive receptors. Reception анастрозола has considerably lowered frequency of development контралатерального a cancer, and this fact is the basis for studying group ингибиторов ароматазы as means of preventive maintenance of a cancer dairy железы in groups with the raised{increased} risk. Подробнее...

To this time concern definition Melnick (1952), A.D.Timofeevskim (1961) with the help of электронно-microscopic technics{technical equipment} of constant presence вирусоподобных телец in папиллломах. Barrett (1954) has established the fact of transfer генитальных кондилом at гетеросексуальных the sexual relations, Dunn and Ogilvie (1968) have allocated virus particles from генитальных warts [4,9]. As the characteristic of cytologic changes in эпителии шейки a uterus, observable at папилломатозе, Aure (1949) described перинуклеарные changes in cells{cages} at research мазков with шейки a uterus. For the description of similar changes Koss, Durfee (1956) have entered into clinical practice the term " койлоцитотическая атипия " for which large cells{cages} with rather small гиперхромным a nucleus surrounded with transparent cytoplasm are characteristic. Authors for the first time have noted communication{connection} between койлоцитотической атипией. дисплазией and РШМ. Woodruff, Peterson (1958) and Pitkin, Kent (1963) have described histologic characteristics of classical forms папилломатозных кондилом; long time папилломатозные кондиломы were considered as unique morphological display папилломавирусной infections of sexual ways [9,10]. Подробнее...