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From all identified types of viruses of papillomas 34 are associated with defeat аногенитальной areas. Viruses of papillomas infect базальные layers эпителия (the most "vulnerable" site the zone of transition multilayered flat эпителия in cylindrical эпителий is). Caused патоморфологические changes Kurz (1993) and Schiffman (1994) are classified by viruses as: 1) good-quality атипия; 2) LSIL (Low-grade Squamous Intraepithelial Lesions) or CIN-I (Cervical Intraepithelial Neoplasia) - дисплазия an easy degree without койлоцитоза or with attributes койлоцитоза; 3) HSIL (High-grade Squamous Intraepithelial Lesions), CIN-II-moderate дисплазия; 4) expressed дисплазия or интраэпителиальный a cancer (in situ) - CIN-III. Discussion concerning classification дисплазии and преинвазивного РШМ till now proceeds. In the domestic literature it is accepted to allocate three degrees of weight дисплазии эпителия шейки a uterus, интраэпителиальный РШМ it is allocated into separate group [10]. The group дисплазий эпителия шейки a uterus is heterogeneous both with патоморфологической, and from the virologic point of view. Now there is no confidence, that various degrees дисплазий are stages канцерогенеза [18]. Подробнее...

Break of a ring molecule virus ДНК can occur in any place, however most frequently - in area Е1/Е2; exception is area URR-Е6-Е7, which интактна as in морфологически not changed эпителии and at дисплазиях, and in tumoral cells{cages}. Disappearance супрессорной causes functions of virus fiber Е2 суперэкспрессию virus онкогенов Е6-Е7, трансформирующее which action promotes a progression неоплазий. It is supposed, that gene Е1 participates in suppression of the virus promotor, consequence{investigation} of a mutation of gene Е1 are activation of a transcription virus генома and increase трансформирующей activity virus онкогенов [16,23]. Подробнее...