анализы по онкологии

The authentic establishment of association папилломавирусов with development генитальной неоплазии has allowed to approach closely to an opportunity to analyze complex{difficult} and questions at issue of correlation caused ВПЧ молекулярно-genetic changes with clinical features and forecast РШМ. Clinical current РШМ is influenced with histologic type and a degree of a differentiation of a tumour, the size of a primary tumour, depth инвазии subject fabrics and involving in tumoral process прилежащих to шейке a uterus of fabrics, лимфососудистого spaces and регионарных лимфоузлов. Forecast РШМ the big sizes of a primary tumour, a low degree of a differentiation of a tumour, presence of metastatic defeat регионарных лимфоузлов worsen, young age of patients [2,14]. Messages, соотносящие молекулярно-genetic determinants of the ВПЧ-INFECTION at РШМ with гистопатологическими both clinical features of tumours and forecast РШМ, contain inconsistent results. ВПЧ type 16 meets in высокодифференцированных плоскоклеточных tumours while ВПЧ type 18 it is associated with плоскоклеточными tumours of a low degree of a differentiation and аденокарциномами [13,14] is more often. Подробнее...

Long enough time dominated the opinion based on statement R.Meyer (1910) about trauma as этиологическом the moment of metaplastic changes эпителия шейки of a uterus. G.Ward (1935) counted, what not breaks шейки a uterus in themselves, and the subsequent infection conducting{leading} to a chronic inflammation, is этиологическим the moment in development карцином. Howard (1951) at research of histologic preparations шейки a uterus at the confirmed inflammation found out метаплазию эпителия in 83 % of cases. A.I.Serebrov (1957) wrote: " ... Not smaller value, than a mechanical trauma, in патогенезе a cancer шейки a uterus has a local infection, more truly, a combination of these two conditions ". Modern epidemiological researches have confirmed these assumptions, having allocated as risk factors РШМ the early beginning of a sexual life, early the first роды, often change of sexual partners, venereal diseases (including at sexual partners). Use of modern methods of contraception also is discussed as a possible{probable} risk factor of a gynecologic cancer. It is established, that use of barrier methods of contraception results in authentic decrease{reduction} in desease РШМ [3,5,14,22,23], application внутриматочных contraceptives does not render influence on desease РШМ [6]. Подробнее...