российский институт онкологии

Thus, gene Е6 is multifunctional fiber, трансактивирующая which activity assumes participation in regulation of a transcription, interaction with a gene р53, his{its} degradation, in infringement of the mechanism of the control of cellular growth and process of a differentiation of cells{cages}. However till now there is no harmonous representation about the mechanism of interaction of virus fiber Е6 with cellular fibers in vivo. Virus fiber Е7 cooperates with cellular fiber Rb105, Rb-related fibers and Н1-киназой. These interactions are the independent processes necessary for effective transformation of cells{cages} by fiber. Fiber pRb (р105) is a product of a gene ретинобластомы, супрессора cellular growth. Подробнее...

Инфицированность ВПЧ type 18 contacts the worse forecast Walker (1989) and Burnett (1992), Riou (1990) and Higgins (1991) specify higher parameters of death rate in case of ВПЧ-NEGATIVE tumours, in researches Hоweey (1991), Sebbelov (1991), Chen (1993), Ikenberg (1994) similar law has not been revealed [цит. On 14]. However results of similar researches are put under doubt by the modern data on revealing sequences virus генома a method полимеразной chain reaction in 95-100 % of cases плоскоклеточного a cancer and аденокарцином шейки a uterus [18,23]. The age of patients, on one data, is not connected to молекулярно-genetic determinants of infection ВПЧ while other authors specify, that ВПЧ type 18 or ВПЧ type 16 come to light at younger patients is more often. Stage FIGO, by results of one researches, has not been connected to молекулярно-genetic determinants of infection ВПЧ [14,18]. Подробнее...