костная онкология

Регуляторная the area virus генома (upstream regulatory region, URR) settles down between the end of area of late genes and the beginning of area of early genes. Open frameworks of reading ORF генома a virus are divided{shared} on early (early, Е) and late (late, L) sites. The early fragment includes genes Е1-Е7 coding synthesis of fibers, responsible{crucial} for various functions in process репликации a virus and transformation of cells{cages}. Genes Е1 and Е2 are responsible{crucial} for репликацию a virus, and also participate in regulation of a transcription virus генома. The product of gene Е1 is responsible for maintenance персистенции virus генома in эписомальной to the form. Gene Е2 codes products which can as a trance - activate, and to suppress экспрессию early genes and энхенсерных sites URR. Трансактивирующий the factor is identified in precancer changes шейки a uterus, репрессирующий the factor in vivo is not identified [16]. Gene Е4 participates during maturing virus particles, genes Е5-Е7 possess трансформирующим potential. Genes Е6 and Е7 are always defined{determined} and экспрессируются in tumours шейки a uterus and received of tumours шейки a uterus cellular lines. The biological effect трансформирующего potential of genes Е6 and Е7 will be considered below. The late fragment генома will consist of genes L1 and L2, coding structural fibers вириона [5,21]. Подробнее...

Modern молекулярно-trouble-shooting tests quickly move ahead in a direction of increase of their sensitivity and specificity. Now for identification virus ДНК various techniques of hybridization ДНК and molecular cloning are used. The most sensitive method now recognizes полимеразная chain reaction with типоспецифическими and species-specific праймерами, allowing to reveal virus sequences in геноме cells{cages} of tumours шейки a uterus in 95-100 % of cases [5,14,18,22]. Now it is identified more than 100 types ВПЧ, are in detail described more than 70 types, the fact is fixed, that certain types ВПЧ can infect strictly certain kind эпителия and to cause characteristic changes. Revealing of multi-variant approach of genotypes ВПЧ and identification of the data specific accumulation about malignant transformation генитальных кондилом have allowed to consider{examine} папилломавирус as possible{probable} этиологический the factor of development РШМ [13,15,20,23]. Подробнее...