младенческий лейкоз

The opportunity of interrelation неоплазий шейки a uterus with venereal diseases was for many years discussed. In group of the women suffering инвазивным РШМ, higher frequency of revealing of nonspecific microflora is marked, switching трихомонадные and гарднерелловы infections [3,6]. Examples of such influence were discussed in attitude{relation} Treponema pallidum, Neisseria gonorrhoeae, Chlamydia trachomatis, a virus of a simple herpes of type 2, a cytomegalovirus, a virus of a papilloma of the person [3,19]. Epidemiological researches have convincingly shown, that a conclusive risk factor of occurrence of precancer changes and a cancer шейки a uterus is генитальная папилломавирусная the infection, accompanying папилломавирусной infections of sexual ways influence at early stages of development неоплазий and do not influence on already arisen РШМ [5,13,14,23]. Подробнее...

Process of integration is accompanied by partial loss of a genetic material of a virus, thus virus a gene irrespective of делеций loses ability to full репликации, and in the cells{cages} containing integrated cellular gene, there is no production of virus particles. Assume, that integration represents активационный the mechanism of a progression неоплазии from дисплазии a heavy degree to a cancer; she{it} originally carries поликлональный character. Most frequently in канцерогенез шейки a uterus are involved certain{determined} speed up chromosomes 5,6,10,11 and 17. Integration virus ДНК induces instability cellular генома and as consequence{investigation} an induction of infringements in the various chromosomes tested on loss of heterozygosity. The site of primary integration virus ДНК is not determined, quite often it{he} settles down near to cellular онкогенов [4]. Подробнее...